Trained in pediatric intensive care medicine, I have had a special interest in the care of children with critical heart diseases that require surgical intervention since fellowship. As a seasoned pediatric cardiac intensive care physician, I have incorporated my clinical experience into translational research works focusing on investigations that explore the molecular basis for critical illness, especially heart disease in children. My own work on the modulation of annexin A2 (A2) and its functional impact on organ dysfunction after cardiopulmonary bypass (CPB) was published in 2023, providing the first look at annexin A2 as a potential therapeutic target for acute lung injury associated with CPB in children in the future. I am thrilled to serve as a co-investigator in the current project, which explores the novel strategy of endothelin-1 inhibition to increase cardiomyocyte proliferation in infants with congenital heart disease. My primary responsibility on the project will involve coordinating recruitment of human subjects and collection of human tissue samples, especially myocardium. My experience in conducting multi-center clinical trials and basic science research give me a solid foundation to serve in this role.