The Pediatric Institute for Heart Regeneration and Therapeutics (I-HRT) is a research institute within the Department of Pediatrics, Weill Cornell Medicine, directed by Bernhard Kühn, MD. This institute seeks to improve health by repairing hearts through guided regeneration. The institute strives to develop a scientific basis for heart regeneration through world-class research and training. The institute incorporates basic, translational, and clinical research. I-HRT’s goal is to translate the strategy of stimulating heart muscle cell regeneration into a therapy.
Affiliated Faculty
- Bernhard Kuhn (Director)
- Honghai Liu (Faculty Member)
- Doreen Hsing (Affiliated/Adjunct Member)
- Rashida Blackwood (Clinical Research Coordinator)
Essential Publications
Elimination of 15N-thymidine after oral administration in human infants
Niyatie Ammanamanchi, Jessie Yester, Anita P. Bargaje, Dawn Thomas, Kathryn C. Little, Shannon Janzef, Kimberly Francis, Jacqueline Weinberg, Jennifer Johnson, Thomas Seery, Tyler Hutchinson Harris, Bryan J. Funari, Kirsten Rose-Felker, Matthew Zinn, Susan A. Miller, Shawn C. West, Brian Feingold, Hairu Zhou, Matthew L. Steinhauser, Timothy Csernica, Robert Michener, Bernhard Kühn
PLoS One
2024, Jan 25
Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts
Han L, Mich-Basso JD, Li Y, Ammanamanchi N, Xu J, Bargaje A, Liu H, Wu L, Jeong JH, Franks J, Stolz DB, Wu YL, Rajasundaram D, Liu Y, Kühn B
Developmental Cell
2022 Oct 24
El Khoudary SR, Fabio A, Yester JW, Steinhauser ML, Christopher AB, Gyngard F, Adams PA, Morell VO, Viegas M, DaSilva J, Da Fonseca Da Silva L, Castro-Medina M, McCormick A, Reyes-Múgica M, BarlasM , Liu H, Thomas D, Ammanamanchi A, Sada R, Cuda M, Hartigan E, Groscost DK, Kühn B
International Journal of Cardiology
2021 Sep 15
Jessie W. Yester, Honghai Liu, Frank Gyngard, Niyatie Ammanamanchi, Katherine C. Little, Dawn Thomas, Mara L.G. Sullivan, Sean Lal, Matthew L. Steinhauser, and Bernhard Kühn.
Nature Protocols
2021, Feb 24
Cardiac Regeneration: Methods and Protocols
(ed. Kühn B, Poss K).
Lamin B2 levels regulate polyploidization of cardiomyocyte nuclei and myocardial regeneration.
Han L, Choudhury S, Mich-Basso JD, Ammanamanchi N, Ganapathy G, Suresh S, Khaladkar M, Singh J, Maehr R, Zuppo DA, Kim J, Eberwine JH, Wyman SK, Wu Y & Kühn B.
Developmental Cell
2020 Apr 06
Honghai Liu, Cheng-Hai Zhang, Niyatie Ammanamanchι, Sangita Suresh, Christopher Lewarchik, Krithika Rao, Gerrida M. Uys, Lu Han, Maryline Abrial, Dean Yimlamai, Balakrishnan Ganapathy, Christelle Guillermier, Nathalie Chen, Mugdha Khaladkar, Jennifer Spaethling, James H. Eberwine, Junhyong Kim, Stuart Walsh, Sangita Choudhury, Kathryn Little, Kimberly Francis, Mahesh Sharma, Melita Viegas, Abha Bais, Dennis Kostka, Jun Ding, Ziv Bar-Joseph, Yijen Wu, Vijay Yechoor, Mousumi Moulik, Jennifer Johnson, Jacqueline Weinberg, Miguel Reyes-Múgica, Matthew L. Steinhauser, Bernhard Kühn.
Science Translational Medicine
2019, Oct 09